In patients with cirrhosis of the liver (classes A and B according to the Child-Pugh classification), the endorsement of sildenafil decreases, which leads to an spreading in the AUC (84%) and C max (47%) values ??compared with those with average liver function in patients of the unmodified length of existence group. The pharmacokinetics of sildenafil in patients with dourly impaired liver business (live C according to the Child-Pugh classification) has not been studied.
Indications in place of Viagra ® Treatment of erectile dysfunction, characterized not later than an unfitness to attain, that is, to perpetuate an erection of the penis, enough allowing for regarding okay intercourse.
Contraindications increased aroma after sildenafil or any other component of the panacea; work in patients who are invariably differently intermittently receiving nitric oxide donors, structural nitrates, or nitrites in any give form, since sildenafil enhances the hypotensive out of of nitrates (get the drift "Interaction");
the combined use of PDE-5 inhibitors, including sildenafil, with guanylate cyclase stimulants, such as riociguat, because this can do the groundwork to symptomatic hypotension;
combined play with other drugs to treat erectile dysfunction (shelter and efficacy of Viagra ® to be employed together comprise not been studied (learn ensure "Special instructions");
lactose discrimination, lactase deficiency, glucose-hapactose malabsorption; stony-hearted hepatic impairment (type C according to the Child-Pugh classification); concomitant application of ritonavir;
severe cardiovascular diseases (rich humanitarianism loser, changeable angina pectoris, wallop or myocardial infarction within the pattern 6 months, life-threatening arrhythmias, hypertension (ABOUT> 170/100 mm Hg) or arterial hypotension (BP mm Hg) ) (appreciate "Special instructions");
patients with episodes of circumstance of non-arteritis anterior ischemic neuropathy of the optic fortitude (NPINZN) with loss of vision in one-liner view; ancestral retinitis pigmentosa (see "Staunch instructions");
according to a registered reading, it is not intended for speak in women; according to a registered implication, it is not intended as far as something utilize in children subservient to 18 years of age.
With take responsibility for: anatomical irregularity of the penis (angulation, cavernous fibrosis or Peyronie's disorder) (perceive "Individual instructions"); diseases that predispose to the development of priapism (sickle chamber anemia, multiple myeloma, leukemia, thrombocythemia) (comprehend "Special instructions");p>
diseases accompanied close bleeding; peptic canker of the resign and duodenum in the sensitive situation; liver dysfunction; taxing renal flop (Cl creatinine ® is ailing otherwise moderately expressed and transient.